6,283 research outputs found
Stereoselective Synthesis of Densely Substituted Tetrahydroquinolines by a Conjugate Addition Nitro-Mannich Reaction with Carbon Nucleophiles
Conjugate addition of an alkyl group to a series of 2-imino-nitrostyrenes and then addition of trifluoroacetic acid initiates a nitro-Mannich cyclisation to give cis,cis-2,3,4-substituted tetrahydroquinolines in good yield and high diastereoselectivity
Asymmetric Intramolecular Conjugate Addition Nitro-Mannich Route to cis-2-Aryl-3-nitrotetrahydroquinolines
Reductive cyclization of 2-iminonitrostyrenes (from the condensation of 2-aminostyrenes with an aldehyde and subsequent nitration of the alkene) using a bifunctional thiourea catalyst and tert-butyl-Hantzsch ester leads to an intramolecular conjugate hydride addition nitro-Mannich reaction to give the corresponding cis-2-aryl-3-nitrotetrahydroquinolines as single diastereoisomers in high yields and enantioselectivities
The effect of a foul release coating on propeller performance
With the imminent ban on the application of coatings of TBT self-polishing co-polymers in January 2003 and their
eventual prohibition in 2008 a great deal of research is being conducted into the performance of the possible alternatives.
As part of the ongoing work investigating the hydrodynamic performance of foul release systems, being carried out at the
University of Newcastle upon Tyne, a study into the possible benefits of their use on propellers has been conducted. The
benefits that this method of propeller protection offers are potential fuel savings from increased propulsive efficiency as
well as lower maintenance costs and a cleaner environment. Initially a literature review exploring the effect of propeller
surface conditions on ship performance and previous work on propeller coatings for merchant ships was conducted.
Theoretical calculations on the possible gains were then explored for a merchant ship propeller type using a propeller
lifting surface analysis program. These showed that the significant losses in efficiency caused by blade roughening can
be avoided by the application of a foul release coating with a surface finish equivalent to a new or well polished propeller
Measuring Accuracy of Automated Parsing and Categorization Tools and Processes in Digital Investigations
This work presents a method for the measurement of the accuracy of evidential
artifact extraction and categorization tasks in digital forensic
investigations. Instead of focusing on the measurement of accuracy and errors
in the functions of digital forensic tools, this work proposes the application
of information retrieval measurement techniques that allow the incorporation of
errors introduced by tools and analysis processes. This method uses a `gold
standard' that is the collection of evidential objects determined by a digital
investigator from suspect data with an unknown ground truth. This work proposes
that the accuracy of tools and investigation processes can be evaluated
compared to the derived gold standard using common precision and recall values.
Two example case studies are presented showing the measurement of the accuracy
of automated analysis tools as compared to an in-depth analysis by an expert.
It is shown that such measurement can allow investigators to determine changes
in accuracy of their processes over time, and determine if such a change is
caused by their tools or knowledge.Comment: 17 pages, 2 appendices, 1 figure, 5th International Conference on
Digital Forensics and Cyber Crime; Digital Forensics and Cyber Crime, pp.
147-169, 201
Representation of Women in Stroke Clinical Trials: A Review of 281 Trials Involving More Than 500,000 Participants
Background and ObjectivesWomen have been underrepresented in cardiovascular disease clinical trials but there is less certainty over the level of disparity specifically in stroke. We examined the participation of women in trials according to stroke prevalence in the population.MethodsPublished randomized controlled trials with ≥100 participants enrolled between 1990 and 2020 were identified from ClinicalTrials.gov. To quantify sex disparities in enrollment, we calculated the participation to prevalence ratio (PPR), defined as the percentage of women participating in a trial vs the prevalence of women in the disease population.ResultsThere were 281 stroke trials eligible for analyses with a total of 588,887 participants, of whom 37.4% were women. Overall, women were represented at a lower proportion relative to their prevalence in the underlying population (mean PPR 0.84; 95% confidence interval [CI] 0.81-0.87). The greatest differences were observed in trials of intracerebral hemorrhage (PPR 0.73; 95% CI 0.71-0.74), trials with a mean age of participants <70 years (PPR 0.81; 95% CI 0.78-0.84), nonacute interventions (PPR 0.80; 95% CI 0.76-0.84), and rehabilitation trials (PPR 0.77; 95% CI 0.71-0.83). These findings did not significantly change over the period from 1990 to 2020 (p for trend = 0.201).DiscussionWomen are disproportionately underrepresented in stroke trials relative to the burden of disease in the population. Clear guidance and effective implementation strategies are required to improve the inclusion of women and thus broader knowledge of the impact of interventions in clinical trials
Mine closure of pit lakes as terminal sinks: best available practice when options are limited?
In an arid climate, pit lake evaporation rates can exceed influx rates, causing the lake to function as a hydraulic terminal sink, with water levels in the pit remaining below surrounding groundwater levels. We present case studies from Western Australia for two mines nearing closure. At the first site, modelling indicates that waste dump covers for the potentially acid forming (PAF) material would not be successful over the long term (1,000 years or more). The second site is a case study where PAF management is limited by the current waste rock dump location and suitable cover materials. Pit lake water balance modelling using Goldsim software indicated that both pit lakes would function as hydraulic terminal sinks if not backfilled above long-term equilibrium water levels. Poor water quality will likely develop as evapoconcentration increases contaminant concentrations, providing a potential threat to local wildlife. Even so, the best current opportunity to limit the risk of contaminant migration and protect regional groundwater environments may be to limit backfill and intentionally produce a terminal sink pit lake
Proposals for evaluating the regularity of a scientist'sresearch output
Evaluating the career of individual scientists according to their scientific output is a common bibliometric problem. Two aspects are classically taken into account: overall productivity and overall diffusion/impact, which can be measured by a plethora of indicators that consider publications and/or citations separately or synthesise these two quantities into a single number (e.g. h-index). A secondary aspect, which is sometimes mentioned in the rules of competitive examinations for research position/promotion, is time regularity of one researcher's scientific output. Despite the fact that it is sometimes invoked, a clear definition of regularity is still lacking. We define it as the ability of generating an active and stable research output over time, in terms of both publications/ quantity and citations/diffusion. The goal of this paper is introducing three analysis tools to perform qualitative/quantitative evaluations on the regularity of one scientist's output in a simple and organic way. These tools are respectively (1) the PY/CY diagram, (2) the publication/citation Ferrers diagram and (3) a simplified procedure for comparing the research output of several scientists according to their publication and citation temporal distributions (Borda's ranking). Description of these tools is supported by several examples
Extremely long quasiparticle spin lifetimes in superconducting aluminium using MgO tunnel spin injectors
There has been an intense search in recent years for long-lived
spin-polarized carriers for spintronic and quantum-computing devices. Here we
report that spin polarized quasi-particles in superconducting aluminum layers
have surprisingly long spin-lifetimes, nearly a million times longer than in
their normal state. The lifetime is determined from the suppression of the
aluminum's superconductivity resulting from the accumulation of spin polarized
carriers in the aluminum layer using tunnel spin injectors. A Hanle effect,
observed in the presence of small in-plane orthogonal fields, is shown to be
quantitatively consistent with the presence of long-lived spin polarized
quasi-particles. Our experiments show that the superconducting state can be
significantly modified by small electric currents, much smaller than the
critical current, which is potentially useful for devices involving
superconducting qubits
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